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The Endocrine Society's clinical practice guidelines on GH use emphasize that IGF-1 measurement can help distinguish between GH-receptor-mediated effects and non-GH-receptor peptide activity [11]

Both have been studied in overlapping contexts (fibroblast proliferation in cited models, tendon repair, muscle injury), but through different enough mechanisms that combination research is scientifically justified

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Some studies suggest potential roles in angiogenesis, collagen-related repair processes, inflammatory signaling, and protection of different tissue types