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This distinction matters for clinical decision-making

The FDA Modernization Act 2.0 (2022) removed the mandate for animal testing before human trials

However, limited data are available regarding the kidney effects of GLP-1 RA in real-world settings [18], especially regarding albuminuria-based outcomes or eGFR slopes

Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL et al (1996)

What started with a single GLP-1 receptor agonist has expanded into a category with multiple mechanisms, escalating potency, and an increasingly complicated decision for patients trying to figure out which one is right for them