Large-scale trials are needed to refine dosing strategies and confirm benefits
463,465 In order to study the effect of SAM on the stability and activity of wild-type CBS and mutant CBS, Krau 463 applied a combination of calorimetric methods, functional assays, and kinetic modeling
Using the data from 19 case-controlled studies, 5 cross-sectional studies, and 3 prospective studies published before 1995, the meta-analysis of Boushey and colleagues (Boushey et al, 1995) relating basal hyperhomocysteinemia to atherosclerotic vascular disease indicates that, above 10 mol/L, a 5 mol/L increment in circulating homocysteine is associated with a significant increase in the risk of coronary artery disease (60% in men and 80% in women)
at the 3 IU per mg convention these map to the International Unit values below
Topical glutathione Glutathione is commercially available as face washes and creams