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Initial evaluation of symptomatic patients should include right upper quadrant ultrasound and laboratory tests including liver function tests (bilirubin, alkaline phosphatase, ALT/AST), complete blood count, and consideration of lipase to assess for pancreatitis

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This extended half-life (approximately 7 days) means the exact time of day matters less than consistent weekly timing

The Toll-like receptor 4 antagonist TAK-242 induces antidepressant-like effects in a rat learned helplessness model of depression through BDNF-TrkB signaling and AMPA receptor activation

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