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This creates a calorie trap where the body is starved of essential nutrients, leading to a cascade of hidden side effects that may be mistaken for the medications direct effects
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The lncRNA FERRIN, which is produced under conditions of glutamine starvation induced by the transcription factor ATF4, interacts with the RNA-binding protein hnRNPK, thereby promoting its binding to and stabilizing SLC7A11, and consequently promoting the proliferation of cancer cells [41]
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423 Predictive biomarkers and patient stratification In the precision medicine era, predictive biomarkers are indispensable for optimizing therapy selection, improving efficacy, and minimizing treatment-related toxicity (Table 4)
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