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It is contraindicated for weight management during pregnancy (Zepbound), and women of reproductive potential should be counseled about potential effects on oral contraceptive efficacy

But clinical evidence that IV glutathione improves outcomes during GLP-1 therapy does not exist

Key secondary endpoints related to physical fitness were changes from randomization to the end of treatment (weeks 052) in: (1) physical functional performance (time to ascend and descend an 11-step stairway twice)

Nevertheless, interindividual response variability, high cost, and adherence challenges may limit widespread clinical implementation

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