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Willems SJ, Coppieters MW, Rooker S, et al

52,53 In a phase 2, multi-center trial conducted at 45 centers, orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide

Overexpression of nuclear receptor subfamily 1, group D member 1 (NR1D1)/Rev-Erba, an orphan nuclear receptor, has been shown to enhance the antimycobacterial properties of macrophages and decrease the survival of M.tb by promoting phagosomelysosome maturation through IL-10 repression in human macrophages[53]

They use prebiotic fiber, probiotics (like Akkermansia muciniphila ), and metabolic compounds (berberine, chromium, 5-HTP) to nudge the body's own GLP-1 production