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Create functional folate deficiency (a buildup of inactive folate that can't do its job), because B12 is a cofactor for the enzyme that turns inactive folate into active folate

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If supplementation is indeed required, it must be preceded by a careful consideration of the patients Se baseline status, gender, weight and so on ( 3.3 Dual role of Se deficiency in cretinism Cretinism often occurs in areas where endemic goiter is prevalent, with mucinous edema cretinism being the main manifestation of hypothyroidism without goiter

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In several studies reported that chronic ROS exposure showed not severe liver injury