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Metformin is contraindicated in patients with an eGFR 4 years) is associated with vitamin B12 deficiency in 10-30% of patients, likely due to interference with calcium-dependent B12 absorption in the terminal ileum
Ferroptosis differs from other programmed cell death due to smaller mitochondria, rupture of the outer mitochondrial membrane, preservation of the plasma membrane, normal nuclear size, and lack of chromatin condensation [9,10,11]
(PubMed) Willett W
It was originally developed for managing Type 2 diabetes, but quickly gained attention for its weight loss benefits
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