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Both peptides show promise, but using them wisely and safely is key to seeing results.

In addition, combined investigations using human HSCR samples and endothelin receptor B-deficient mice have demonstrated impaired epithelial regeneration and disrupted stromal-epithelial signaling, characterized by depletion of LGR5 stem cells and a shift toward proinflammatory stromal populations, which may contribute to Hirschsprung-associated enterocolitis 136

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Briefly, total RNA was extracted using TRIzol reagent (Takara, Shiga, Japan)