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Ferroptosis is an iron-dependent, non-apoptotic form of cell death characterized by lipid peroxidation-driven loss of plasma membrane integrity, primarily mediated through three interconnected mechanisms: iron metabolism dysregulation, glutathione peroxidase 4 (GPX4) inactivation with concomitant glutathione depletion, and lipoxygenase (LOX)-catalyzed lipid peroxidation