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In particular, LC3B and SQSTM1, two major autophagy regulators, are significantly upregulated alongside increased GFAP expression

Sonya Babu-Narayan, clinical director at the British Heart Foundation and consultant cardiologist, said: These intriguing results demonstrate that the benefits of medications like semaglutide on heart health go beyond weight loss alone. However, she commented: More research will be needed to unravel the other mechanisms of action behind the cardiovascular benefits beyond weight and fat loss, such as improvements in blood vessel health, control of blood pressure and blood sugar or inflammation

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Even persistent nausea, which does not directly cause fluid loss, leads to reduced water intake because the last thing a nauseated person wants to do is drink