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Vitamin B12 is converted in the body to methylcobalamin and adenosylcobalamin to produce activity, and methylcobalamin is involved in folate metabolism

Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses

It produces the most consistent results, allows precise dose titration, and matches the route used in nearly all preclinical research

The fundamental difference between these two compounds is the receptor combination they target and the downstream metabolic effects each receptor produces