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Optical biosensors, such as ATeam, Perceval, iATPSnFR, and Syn-ATP, have elucidated the energy demands of synaptic activity, particularly highlighting the substantial ATP consumption during synaptic vesicle recycling at presynaptic terminals [35]
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This overlap provides a biologically plausible framework through which GLP-1 signaling may help stabilize cellular energy regulation, particularly in the context of metabolic stress, even if direct effects on intrinsic aging processes remain to be fully established
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