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The active ingredient in Zepbound, Tirzepatide , which is also present in the drug Mounjaro, prescribed off-label for weight loss, functions by mimicking glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
Clinical Evidence: What Trials and Real-World Data Show Pivotal trials for semaglutide (SUSTAIN and SELECT series) did not identify UTI as a primary safety signal
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Hamasaki, H
121 Overall, these data accumulate to show that GLP-1 RAs provide not only metabolic and mitochondrial effects but also meaningful clinical impact for vascular and neuroendocrine protection that may ultimately decrease age-related decline in cardiovascular health, musculoskeletal health, and cognitive health
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