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Recent studies have found that increased level of GLP-1 in the hippocampus restores GABA and reverses this neurotoxic effect by reducing oxidative stress through the SIRT1/Nrf2/HO-1 pathway, promoting autophagy through the AMPK/mTOR pathway, and alleviating hippocampal apoptosis by inactivating pro-apoptotic kinase GSK-3 (Arab et al., 2023)
Diabetes 2014, 63, 33463358
Regulatory status, safety profiles, and long-term data differ significantly between the two categories
Whether GLP-1R is expressed in endothelial cells remains controversial 28,33,34,35
Credit: Instagram/@robertwblove Robert Love, a neuroscientist who helps people prevent Alzheimers disease using science-based strategies, offers a practical perspective
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