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Gurram PC, Manandhar S, Satarker S et al (2025) Substance P mitigates lipopolysaccharide induced cognitive impairment in rats in a dose dependent manner
Stacking increases complexity, and while individual peptides have established safety profiles in clinical settings, self-experimentation is strongly discouraged due to potential risks
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In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases
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