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Blue Cross Blue Shield of Massachusetts and Point32Health are discontinuing coverage of GLP-1 medications for weight loss, and CVS Caremark has restricted its formulary to Wegovy, removing Zepbound
Claims that the combination is "proven" to outperform either compound are not supported by the published literature
The primary outcome was the first occurrence of MACE, defined as death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke
For these reasons, definitely avoid goldenseal
A post-mortem study of human pancreases demonstrated proliferative effects in those cases with GLP-1RA use, which were manifest by an increased mass of the pancreas along with increased frequency of PanIN1 and PanIN2 lesions compared to diabetes controls 23
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