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Data availability Proteomics data is deposited in the ProteomeXchange (PRIDE) repository with accession number PXD056782
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Blood pressure (BP), anthropometric characteristics, markers of liver function, metabolic indices (plasma glucose, lipid profiles, uric acid, free fatty acid and insulin) and hypersensitivity C-reactive protein were measured
Specifically, retatrutide simultaneously activates three distinct hormone receptors: GLP-1 (glucagon-like peptide-1) receptors promoting insulin secretion, reducing appetite, and slowing gastric emptying GIP (glucose-dependent insulinotropic polypeptide) receptors enhancing insulin response and supporting fat metabolism Glucagon receptors increasing energy expenditure and promoting hepatic fat breakdown It is important to note that glucagon receptor activation can, in isolation, raise blood glucose levels
The structure of these 2 compounds are shown below
