doi: 10.1186/s12917-018-1678-7 11 JodoinJHinckeMT
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According to the UK SmPC, the most common side effects include: Nausea (very common, affecting more than 1 in 10 people): Usually most pronounced during the first few weeks of treatment and often diminishes with continued use Diarrhoea (common, affecting up to 1 in 10 people): Typically mild to moderate in severity Vomiting (common): More frequent at higher doses Constipation (common): May occur alongside other gastrointestinal effects Abdominal pain or discomfort (common): Relatively frequent during treatment initiation Decreased appetite (very common): An expected effect related to the medication's action Dyspepsia/indigestion (common): May contribute to discomfort after eating Beyond gastrointestinal effects, other recognised adverse reactions include injection site reactions (redness, itching, or swelling at the subcutaneous injection site), fatigue , and dizziness

Acknowledgements This work was supported by National Natural Science Foundation of China (82170873, 82371424), and Tsinghua University Spring Breeze Fund (20211080005)
The TRIUMPH-4 study included the standard suicide-risk screening tool (the C-SSRS) and didnt flag a difference between retatrutide and placebo