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Decreased appetite was reported by 11-31% among retatrutide-treated subjects (vs 9% placebo) in the obesity trial and by 10% (vs 2% placebo) in the diabetes trial [3,4]
the efficacy of the combination (known as CagriSema) on weight loss in persons with either overweight and coexisting conditions or obesity is unknown, explained the study authors
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This might include temporary use of short-acting insulin, adjustment of other diabetes medications, or increased glucose monitoring to maintain blood glucose targets of 80-180 mg/dL per American Diabetes Association guidelines
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