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It is produced through solid-phase peptide synthesis (SPPS) and supplied in lyophilized form for controlled laboratory use
Nature 505 , 559563 (2014)
Structure [edit] The glutathione binding site, or "G-site", is located in the thioredoxin-like domain of both cytosolic and mitochondrial GSTs
Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress
Chem Res Toxicol
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