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380 However, NAD + depletion exacerbates oxidative damage via reducing the antioxidant defense capacity, resulting in impaired cell proliferation and increased cell death

Which raises an important question: If youre optimizing hormones but ignoring cellular defense, are you really optimizing health

Robichaud S, Fairman G, Vijithakumar V, Mak E, Cook DP, Pelletier AR, Huard S, Vanderhyden BC, Figeys D, Lavalle-Adam M, Baetz K, Ouimet M (2021) Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway