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As a dual GLP-1 and GIP receptor agonist, Tirzepatide affects multiple pathways simultaneously: It slows gastric emptying, enhances insulin secretion in a glucose-dependent manner, suppresses glucagon secretion, and powerfully suppresses appetite

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First, they act on the appetite centers in your brain to reduce hunger and food cravings

Notably, semaglutide was associated with a reduced risk of cognitive deficits and dementia compared to sitagliptin and glipizide, though no significant difference was found when compared to empagliflozin