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Freeze-thaw cycling can disrupt the copper coordination sphere in addition to degrading the peptide backbone, so single-use aliquots are preferable to repeated access of a single stock

The most common side effects are nausea and diarrhoea

Gclc fl/fl mice were described previously 127 and were crossed to Mb1-Cre + expressing mice 46 to obtain the Gclc fl/fl Mb1-cre strain

Additionally, nausea and reduced food intake in the first 12 weeks can deplete electrolytes like sodium and potassium, further destabilizing fluid balance and triggering lightheadedness

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