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Abdominal pain and discomfort Abdominal pain was reported in clinical trials at rates modestly above placebo

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Conversely, low ChaC1 expression is associated with increased secretion of inflammatory markers interleukin-8, interleukin-6 and prostaglandin E2 in the presence of lipopolysaccharide and flagellin stimulation (132)

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Hudson & Tabet 2003 Cochrane Review: A Cochrane Review of 15 clinical trials (including 13 of those in the meta-analysis above) assessed 1 to 3 g/day ALCAR supplementation versus placebo over 12 to 52 weeks in participants with mild to moderate dementia or cognitive decline