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Clinical implications and practical recommendations In patients with T2DM and established heart failure, SGLT2 inhibitors currently have the strongest evidence base for improving HF outcomes and should be prioritized when not contraindicated [8, 11, 45]
Many areas prioritise BMI 35 and above, and treatment is usually through specialist weight-management services with defined criteria and long waiting lists
The following peptides represent the strongest candidates based on mechanism complementarity, safety profiles, and documented outcomes from the research community
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