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Streptozotocin (STZ) was purchased from OKA (Beijing, China)

Long-term alcohol consumption leads to liver inflammatory response, mainly immune cells recognize PAMP or DAMP through PRR, such as Toll-like receptor (TLR), and initiate transcriptional activation of proinflammatory mediators

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The clinical value of GLP-1 therapy depends on the patient, the indication, the dose, the response, the side effects, the nutrition plan, the muscle-preservation strategy, and the larger medical context