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Mechanism: Semaglutide works primarily through appetite suppression by acting on GLP-1 receptors in the brain and gut

Additional objectives were to further assess the safety of VPA in children with SMA, to assess performance of selected outcome measures for use in a multi-center clinical trials setting and to look for evidence that would support a biologic effect of VPA in these subjects, such as changes in SMN expression, electrophysiologic outcomes, or both

Presented for research literature review only Shaw KM et al

Current multisociety guidance recommends an individualised approach

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