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Stockwell in 2012 as an iron-dependent type of cell death that is driven by lipid reactive oxygen species (ROS) [3,4,5] and is significantly different from other regulated cell death forms such as apoptosis [6, 7], autophagy [8, 9], cuproptosis [10, 11], necroptosis [12, 13], and pyroptosis [13, 14] in terms of cell morphology, biochemistry, and genetics (Fig