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The study found no significant differences in systemic side effects between routes, but noted that injection site reactions were the leading cause of treatment discontinuation (3% of injectable users versus 1% of oral users discontinuing due to GI upset)

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Importantly, these medications treat obesity as an ongoing condition: research consistently shows that much of the lost weight is regained when treatment stops, so they are intended for long-term use paired with sustained lifestyle changes and regular follow-up

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