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doi: 10.1073/pnas.1809548115 145 HouWXieYSongXSunXLotzeMTZehHJ3rdet al
Operates at the nuclear protein-interaction level: Unlike metabolic or hormonal peptides that act on membrane receptors, FOXO4-DRI functions by disrupting nuclear protein interactions
Glutathione reductase reduces oxidised glutathione to the reduced sulfhydryl form, which is an important cellular antioxidant, and a high ratio of reduced to oxidised glutathione is important for protection against oxidative stress
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