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After 60 min of perfusion, the control aCSF was replaced with one containing either vehicle or the protein kinase A (PKA) inhibitor H89 (Sigma-Aldrich, 250 M)
Personally, I see manufacturing capacity as the bigger challengedoes Sandoz have the ability to ramp up mass production to meet massive global demand
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High mobility group box 1 protein inhibits the proliferation of human Mesenchymal stem cells and promotes their migration and differentiation along Osteoblastic pathway
The key lesson from ACE-031 was that broad TGF-beta superfamily inhibition produces unacceptable off-target effects, particularly vascular toxicity
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