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However, a significant decrease in insulinotropic activity was observed with GIP in diabetic patient with hyperglycemia, whereas relatively preserved activity was noted with GLP-1 in the same patients (58), suggesting divergent effects of GIP and GLP-1 on -cells ( Figure 1 Section B)
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GLP-1 is released postprandially by intestinal L cells and its activation of GLP-1 receptors (GLP-1Rs) on cells stimulates insulin biosynthesis/secretion
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