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Statistical analyses were performed in RStudio using packages with ggpubr (48), FSA (49), lmerTest (50), emmeans (51), and base functions from the stats package
The renal protective effect appeared to be mediated through anti-inflammatory and anti-apoptotic pathways activated by GHS-R1a signaling, independent of the GH-elevating effect
In aging models, it restores youthful gene expression patterns, increasing protective factors and reducing genes associated with inflammation or degeneration
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