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In this context, our data with nifedipine can be understood
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Microdoses are used off-label to mitigate these side effects
Multifunctional nanoplatforms are most valuable when these barriers are translated into clear design objectives, including improved tumor access and retention, vascular and stromal normalization, TME-responsive release or activation, immune priming or intratumoral reprogramming, and imaging-guided treatment planning
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