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Proposed mechanisms include enhanced long-term potentiation (a cellular correlate of learning), increased brain-derived neurotrophic factor expression, reduced neuroinflammation, and protection against oxidative stress
Laboratory testing to evaluate metabolic health markers, hormonal status, and nutritional parameters 4
Open Neuroendocrinol
This occurs because GLP-1 receptor activation influences areas of the brain involved in appetite regulation, particularly the hypothalamus and brainstem
PDE1B inhibition primarily enhances D1 receptor-mediated signaling, improving cognitive and negative symptoms, whereas PDE10A inhibition targets D2 receptor-mediated hyperactivity to alleviate positive symptoms
