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Compounds that appeared promising in preclinical and early clinical data have failed in later-phase trials repeatedly
Although direct assessment of spermatogenesis using histomorphometric indices (e.g., Johnsen score) was not conducted, the observed decline in sperm parameters and the histological disruption of germinal epithelium indirectly reflect compromised spermatogenic activity
Ninety percent of alcohol consumed passes through the liver
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They compared a target of 4.0 g/day against typical European intakes which range from 4.2 to 8.6 g/day in adults and believed 4.0 g/day to be a practical amount
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