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Metformin induces the M2 macrophage polarization to accelerate the wound healing via regulating AMPK/mTOR/NLRP3 inflammasome singling pathway

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3 Possible mechanisms of lycopene in managing premalignant lesions of digestive tract 3.1 Antioxidative mechanisms Lycopene is a potent antioxidant and has strong capacity to protect against oxidative damage, therefore playing a crucial role in treating selected disorders associated with oxidative stress, including some of the precancerous lesions (Figure 1)

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Mice with a deficiency of key components in the NF-B pathway die as a result of massive hepatocyte apoptosis induced by TNF 37,38 , supporting the critical role of maintenance of hepatocyte NF-B pathway in protecting against TNF cytotoxicity