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Key symptoms include: Fatigue: A pervasive sense of tiredness that does not improve with rest

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Because the skin doesn't have time to contract and adapt to this new, smaller underlying structure, it leads to: Increased skin laxity (sagging) Prominent jowls Hollowed temples and under-eyes Deeper nasolabial folds (smile lines) Want to learn more

Rare cases in two Chinese MEN2A families with RET C634Y germline mutation a systematic review of literature