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Nevertheless, under physiological conditions, in most tissues mitochondria are the major contributors to the cellular ROS production [28,29,30,31], mainly as a side effect of aerobic respiration via oxidative phosphorylation (OXPHOS) occurring on the inner membrane of the mitochondrion [32, 33], but also through other metabolic routes, such as pentose-phosphate pathway and glutathione (GSH) metabolism [34]

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In 1999, orlistat became the first drug approved for chronic weight management, acting by reducing intestinal fat absorption [9]

Development of roGFP2-derived redox probes for measurement of the glutathione redox potential in the cytosol of severely glutathione-deficient rml1 seedlings

Human trials confirm these anti-allergic effects in real-world scenarios