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After extensive experiments, MC3181 was deemed the more promising compound of the two, due to it having a 50-fold rise in aqueous solubility and higher selectivity toward GST
2006, pp
Reconstitution makes it worse by fixing the proportions permanently, so the basic move of experimental design, varying one factor while holding the others constant, is unavailable for the life of that solution
However, the limited follow-up duration of 6 months raised concerns about potential reverse causality, as undetected suicidal ideation and medical conditions might have influenced the choice of particular anti-obesity or anti-diabetic drugs
& LeRoith, D., Endocrinology 4
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