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TB 500 is found at its highest concentration in platelets and white blood cells
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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)
Also, just like methylcobalamin, methylfolate carries a methyl group, further helping replenishing your methyl group stores, regardless of the folate
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