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They can support mechanistic hypotheses about endothelial response and microvascular repair, but they do not establish human wound healing efficacy, cardiovascular benefit, clinical safety, or suitability for any condition where abnormal angiogenesis could be biologically relevant

The body cannot produce B12 naturally, so it must be obtained through diet (primarily animal products) or supplementation

Some practitioners theorize that local administration to abdominal fat may enhance regional lipolytic effects, though this has not been conclusively proven

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