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These cells are uniquely responsive to fungal antigens and their metabolites, including mycotoxins such as gliotoxin, ochratoxin A, and aflatoxins 15

Grx gene silencing in hepatocytes further sensitized hepatocytes to TNF-mediated killing

This binding triggers the release of stored growth hormone while simultaneously suppressing somatostatin, the hormone that normally inhibits GH release

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At the cellular level, HO-1 exists in the endoplasmic reticulum, mitochondria, nucleus, and plasma membrane 45