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79 However, the FDA revised its guidance in 2020, moving toward a risk-based approach in which the need for a cardiovascular outcome trial is determined based on the drugs characteristics, safety profile, and existing cardiovascular risk data

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Fiber also triggers GLP-1 by slowing gastric emptying since it digests slower

Some clinicians may choose a shorter or longer washout period this should be thoughtfully justified, taking into consideration all factors, such as the patients medical history, how they have responded to treatment thus far and even how the patient would feel having a certain length of time for the washout period