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It's regulating more than 5% of your protein encoding human genome
doi: 10.1016/j.gtc.2016.09.007 28 WaltersWAXuZKnightR
The liver is a major site of methionine metabolism and SAM production
Researchers demonstrated that nuclear HDAC1-3, in association with SIRT (dual classified into class III HDACs), exhibited vibrant activities towards delactylases in vitro and inhibited Kla of both H3K18 and H4K5, among which HDAC3 predominates as the leading eraser in a zinc-dependent manner [83]
STAT3 is highly expressed in various tumor cells [138, 139]
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