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Gastrointestinal Tract : GLP-1 receptors in the stomach and intestines delay gastric emptying and reduce gastric motility
Other factors include: Underlying cause of deficiency : Pernicious anaemia, malabsorption disorders, or dietary insufficiency may affect treatment response Medication use : Metformin and proton pump inhibitors can reduce gastrointestinal B12 absorption (though this does not affect the efficacy of intramuscular injections) Individual variation : Differences in how efficiently your body utilises the injected vitamin Adherence to treatment schedule : Missing injections or delaying maintenance doses can slow recovery Discussing these factors with your healthcare provider helps set realistic expectations for your treatment journey
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A Phase I clinical trial established the dosing range of 0.01 to 0.03 mg/kg body weight, with significant tanning after five doses (Dorr et al
