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2012;303(4):R38794
doi: 10.3389/fphar.2022.969107 Received 14 June 2022 Accepted 12 September 2022 Published 03 October 2022 Volume 13 - 2022 Edited by Dan-Qian Chen, Northwest University, China Updates Copyright 2022 Chen, Ye, Wang, Liu, Wang, Wang, Xu and Gong
For example, in pancreatic cancer, the inflammasome component NLRP4 mediates PARPi resistance by promoting NOXO1 expression, which inhibits nuclear translocation of SIRT7, thereby enhancing ROS-induced autophagy and reactivating DDR via reduced H2AX accumulation and impaired BRCA1RAD51 complex formation
Supportive peptides like BPC-157 work indirectly by addressing obstacles that prevent consistent effort
True hydration requires both water AND electrolytes
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