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But how much of a difference did it make, and why does it matter

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15 While rasburicase use is contraindicated in patients with G6PD deficiency, the acute risk of morbidity and mortality associated with untreated TLS creates a clinical dilemma

This buildup of cells that are no longer dividing is called senescence, and its a main driver of metabolic and age-related disease.8 Worsening cellular function leads to other problems that we don't necessarily classify as diseases but that accompany aging and contribute to our eventual demise